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Tidligere var melatonin reseptbelagt og ikke mulig å fileå uten rekvisisjon fra lege, Gentlemen etter at melatonin ble tillatt for salg uten resept, har dette blitt et vanlig virkemiddel i reseptfri sovemedisin.Guy har ikke sett alvorlige bivirkninger eller avhengighet ved korttidsbruk av melatonin, og det regnes som trygt ved korttidsbehandling.

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